Nitric oxide then initiates a chemical chain reaction that causes the smooth muscle surrounding blood vessels to relax. This in turn leads to the dilatation of the blood vessels and improved blood flow. Nitroglycerin, a medication commonly given to cardiac patients, has a similar mechanism of action. It too is converted into nitric oxide, which then leads to dilated blood vessels, improved blood flow, and consequently lower blood pressure and less angina.
Nitroglycerin, whether as a spray, a pill, or a patch has been well studied in cardiology whereas arginine has much less evidence behind. To some extent arginine, like nitroglycerin, can help lower your blood pressure. However, the magnitude of this benefit appears to be quite small and arginine only seems to lower your blood pressure by a few points. Thus the clinical significance of this blood pressure lowering is debatable. Also, the existing trials should be interpreted with caution given their small size in total 11 trials only comprised patients as small trials are more prone to random error skewing the results.
Also the varying doses of arginine used make any comparisons and attempts to combine the data statistically tricky. But the most important factor to consider is that lowering your blood pressure is not the endpoint you should be keeping in mind. Physicians try to lower blood pressure, not as an end in and of itself but for the purpose of preventing heart attacks and strokes. A JAMA study did in fact look at arginine vs. Don't take L-arginine supplements if you've had cold sores or genital herpes.
Too much L-arginine in your system can activate the virus that causes those conditions. A healthy diet and regular exercise are among the best ways to keep your blood pressure healthy. If you're thinking about taking an herbal or dietary supplement, such as L-arginine, talk to your doctor first.
Some supplements can interact with blood pressure medications or make certain health conditions worse. All rights reserved. Terms of Use. Talk to a Beacon Provider about High blood pressure. L-arginine drug interactions It's important to know that L-arginine supplements can interact with some medications, including: Blood thinners, including aspirin and warfarin Certain diuretics Nitroglycerin Some high blood pressure medications Erectile dysfunction drugs Diabetes medications Who shouldn't take L-arginine Don't take L-arginine if you've had a heart attack.
Diabetes Care 19 : — Asagami , T. Metabolism 51 : — Ziccardi , P. Conference proceedings are published as a supplement to The Journal of Nutrition. Guest Editors for the supplement were Sidney M. Morris, Jr. The author is the recipient of a mentored patient-oriented research career transition award from the NIH HL Oxford University Press is a department of the University of Oxford.
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Volume Article Contents Abstract. Endothelial dysfunction in hypertension. Asymmetric dimethylarginine. Future directions. L-Arginine and Hypertension. Noyan Gokce Noyan Gokce. E-mail: Noyan. Gokce bmc. Oxford Academic. Select Format Select format. Permissions Icon Permissions. Abstract Hypertension is a major healthcare problem afflicting nearly 50 million individuals in the United States.
L-arginine , hypertension , endothelium , nitric oxide. Improved endothelial vasomotor function Enhanced vascular NO synthesis Reduced endothelin-1 and angiotensin II activity Favorable alteration of ADMA:l-arginine ratio Modulation of renal hemodynamics Reduced oxidative stress Improved insulin sensitivity. Open in new tab. Risk factor. Defining level. Google Scholar Crossref. Search ADS. Residual lifetime risk for developing hypertension in middle-aged women and men: the Framingham Heart Study.
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. Abnormal endothelium-dependent coronary vasomotion in hypertensive patients. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. Preserved endothelium-dependent vasodilation in patients with essential hypertension.
Effect of local intra-arterial N G -monomethyl-l-arginine in patients with hypertension: the nitric oxide dilator mechanism appears normal. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery.
Adaptation to increased dietary salt intake in the rat: role of endogenous nitric oxide. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Defective l-arginine—nitric oxide pathway in offspring of essential hypertensive patients.
Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. Google Scholar PubMed. Prognostic significance of endothelial dysfunction in hypertensive patients. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. Effect of l-arginine on human coronary endothelium-dependent and physiologic vasodilation.
Long-term l-arginine supplementation improves small-vessel coronary endothelial function in humans. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension.
Acute intravenous l-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels. Intravenous administration of l-arginine inhibits angiotensin-converting enzyme in humans. Failure of l-arginine to induce hypotension in patients with a history of accelerated-malignant hypertension.
The hypotensive effect of l-arginine is associated with increased expired nitric oxide in humans. Chronic l-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Effect of l-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension. Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Vascular endothelial dysfunction resulting from l-arginine deficiency in a patient with lysinuric protein intolerance.
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Asymmetric dimethylarginine ADMA : a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. The vascular effects of l-arginine in humans: The role of endogenous insulin. Vascular effects of acute hyperglycemia in humans are reversed by l-arginine: evidence for reduced availability of nitric oxide during hyperglycemia.
Blood pressure and metabolic changes during dietary l-arginine supplementation in humans. Long-term oral l-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Effects of low-dose l-arginine on insulin-mediated vasodilation and insulin sensitivity. Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes.
Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Seventh Report of the Joint National Committee. N G -monomethyl-l-arginine. National, Heart, Lung, and Blood Institute. Issue Section:. Download all slides. View Metrics. Email alerts Article activity alert.
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